The focus of my research group is on alternative splicing. Alternative splicing is the main process through which genes can express multiple protein isoforms. Over two thirds of human genes are alternatively spliced and it is estimated that 15% of all disease-associated mutations in humans affect alternative splicing.
Current projects
- Involvement and targeting of the SR protein kinases SRPK1 and CLK1 in cancer
- Alternative splicing of VEGF, HER2, ERG, and the Insulin Receptor
- Cellular adaptation to hypoxia through regulated alternative splicing
- The role of ERG and its splice isoforms in prostate and other types of cancer
- Function of stress-induced Arabidopsis mRNA-binding proteins atGRP7/8/2
- Function of Chlamydomonas reinhardtii RNA-binding protein CrGRP1 in stress adaptation
- Textbook: The Molecular Biology of RNA. Elliott and Ladomery. First edition published in 2011, Oxford University Press. Second edition published in 2016.