Ladomery Lab RNA Biology Group

Research Highlights

• Hypoxia leads to significant alternative splicing changes and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
  BMC Cancer 18:355 (2018)
• Residual ground-water levels of the neonicotinoid thiacloprid perturb chemo-sensing of Caenorhabditis elegans
  Ecotoxicology 26, 981-990 (2017)
• The Scd6 protein xRAPB has properties different from RAP55 in selecting mRNA for early translation or intracellular distribution in Xenopus oocytes
  Biochim Biophys Acta 1849, 1363-1373 (2015)
• SRPK1 inhibition and modulation of VEGF alternative splicing as a potential therapeutic strategy in prostate cancer
  Oncogene 34, 4311-4319 (2015)
• Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, and hence angiogenesis, growth and resistance
  Molecular Oncology 9, 167-178 (2015)
• Quantitative analysis of ERG expression and its splice isoforms in formalin fixed paraffin embedded prostate cancer samples: association with seminal vesicle invasion and biochemical recurrence
  Am J Clini Pathol 142, 533-540 (2014)
• WT1 mutants reveal SRPK1 to be a novel downstream angiogenesis target by altering VEGF splicing
  Cancer Cell 20, 768-80 (2011)
• Regulation of Vascular Endothelial Growth Factor Splicing from pro-angiogenic to anti-angiogenic isoforms - a novel therapeutic strategy for angiogenesis
  J Biol Chem 285, 5532-5540 (2010)
• Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by known splicing and growth factors
  J. Cell Sci. 121: 3487-3495 (2008)
• The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron
  Genes & Dev. 20: 1597-1608 (2006)
• Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation
  Hum. Mol. Genet. 13: 235-246 (2004)