Ladomery Lab
RNA Biology Group
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Research Highlights
Hypoxia leads to significant alternative splicing changes and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
BMC Cancer 18:355
(2018)
Residual ground-water levels of the neonicotinoid thiacloprid perturb chemo-sensing of Caenorhabditis elegans
Ecotoxicology 26, 981-990
(2017)
The Scd6 protein xRAPB has properties different from RAP55 in selecting mRNA for early translation or intracellular distribution in Xenopus oocytes
Biochim Biophys Acta 1849, 1363-1373
(2015)
SRPK1 inhibition and modulation of VEGF alternative splicing as a potential therapeutic strategy in prostate cancer
Oncogene 34, 4311-4319
(2015)
Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, and hence angiogenesis, growth and resistance
Molecular Oncology 9, 167-178
(2015)
Quantitative analysis of ERG expression and its splice isoforms in formalin fixed paraffin embedded prostate cancer samples: association with seminal vesicle invasion and biochemical recurrence
Am J Clini Pathol 142, 533-540
(2014)
WT1 mutants reveal SRPK1 to be a novel downstream angiogenesis target by altering VEGF splicing
Cancer Cell 20, 768-80
(2011)
Regulation of Vascular Endothelial Growth Factor Splicing from pro-angiogenic to anti-angiogenic isoforms - a novel therapeutic strategy for angiogenesis
J Biol Chem 285, 5532-5540
(2010)
Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by known splicing and growth factors
J. Cell Sci. 121: 3487-3495
(2008)
The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron
Genes & Dev. 20: 1597-1608
(2006)
Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation
Hum. Mol. Genet. 13: 235-246
(2004)