Ladomery Lab RNA Biology Group


Ladomery Lab
Southwest UK RNA Club

Invited Reviews

Masking of mRNA by Y-box proteins

FASEB J. 10: 435-443 (1996) - PMID: 8647342

Authors: Ladomery M, Sommerville J

Abstract

The Y-box proteins are defined by their ability to bind to Y-box promoter elements and to help regulate transcription of a wide variety of genes. However, Y-box proteins are also identified as abundant proteins in the cytoplasm of germ cells, where they are found bound to stored mRNA molecules. Binding of Y-box proteins to mRNA sequences, both in vitro and in vivo, has been shown to effect their translational repression (’‘masking’‘). Here we discuss the ability of Y box proteins to recognize different nucleic acid structures and to become involved in regulation of both transcription and translation.

Keywords: RNA-BINDING-PROTEINS,MESSENGER-RIBONUCLEOPROTEIN PARTICLES,OOCYTE-SPECIFIC PROTEINS,COLD-SHOCK PROTEIN,XENOPUS-OOCYTES,ESCHERICHIA-COLI,BACILLUS-SUBTILIS,TRANSLATION,LAEVIS,DOMAIN