Alternative splicing in the Hippo pathway - implications for disease and potential therapeutic targets
Genes, in press, ref genes-269900 (2018) -
Authors: Sean Porazinski and Michael Ladomery
Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether or not these processes offer new potential therapeutic targets.
Keywords: Hippo pathway; alternative splicing; YAP; splice-switching oligonucleotides; gene therapy